Category: Uncategorized

Protected: THCA is virtually impotent at the cannabinoid receptors

The Cannabis plant produces cannabinoids in their acidic form —as anyone who has tasted a freshly pruned bud can attest. In recent years, doctors and patients have become very interested in THC Acid, which is said to be non-psychoactive while exerting anti-seizure effects and other medical benefits. Two isomers of THC Acid  have been identified —THCA-A and THCA-B. “Cannabis primarily biosynthesizes THCA-A, and this isomer has been the focus of most pharmacological studies,” Dr. John McPartland and pharmacologists from New Zealand note in a paper published in Cannabis and Cannabinoid Research. “Conversely, THCA-B has greater stability and crystalizes more readily.”  Thus THCA-B is the molecule used in computer modeling studies of cannabinoid receptors. Chemical Structures (from left) of THC, THCA-A, and THCA-B Researchers investigating THCA’s mechanism of action are confounded by how readily it transforms into neutral THC by loss of a carboxyl group (COOH). This decarboxylation occurs not just when THCA is smoked or baked,  but even at room temperature. McPartland et al report that the THCA-A standard provided them by Cayman Chemical —supposedly 100% pure— turned out to be 2% THC. McPartland et al disagree with Dr. Guillermo Moreno-Sanz, a researcher at UC Irvine School of Medicine, who contends that THCA-A  is non-psychoactive because it cannot cross the blood-brain barrier. Moreno-Sanz concluded in a paper wittily entitled “Can you pass the acid test?” (and in a talk to the Society of Cannabis Clinicians)...

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The DIS-implementation of Prop 215

Numerous government agencies have been working hard to implement California’s “legalization” law that takes effect next year. Contrast the bureaucats’ activity with their response to California voters passing legalizing cannabis for medical use, when they did less than zero. Passing an initiative is only half the battle, it turned out. Implementation is everything. In 1996, California’s top Law Enforcers actually tried to get Prop 215 overridden by the feds. As journalist Pat McCartney wrote in O’Shaughnessy’s, “Documents obtained by this reporter from state and local agencies, and litigants in the Conant v. McCaffrey case, reveal California officials committing acts...

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CBD promotes cardiovascular health

Saorise O’Sullivan, PhD, summarized the extremely promising results of her research at this year’s meeting of the International Cannabinoid Research Society in Montreal. O’Sullivan is Associate Proferssor on the Faculty of Medicine and Health Sciences at the University of Nottingham.  Her talk on “Cardiovascular Effects of Cannabinoids” won the ICRS’s Young Investigator Award. Here’s the abstract: Cannabidiol (CBD) is a non-psychoactive phytocannabinoid already on the market as part of a licensed treatment in multiple sclerosis (Sativex® GW Pharmaceuticals, Cambridge, UK). CBD alone (Epidiolex®, GW Pharmaceuticals, Cambridge, UK) is also in clinical trials in children with intractable epilepsies and has...

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CMCR Doesn’t Stand for ‘California…’

By Fred Gardner Igor Grant, MD, a professor of psychiatry at UC San Diego, has been the director of California’s Center for Medical Cannabis Research since its inception in 2000. Grant recounted the history of the CMCR to a respectful audience at the Patients Out of Time conference in Berkeley last weekend. In 1999 State Sen. John Vasconcellos arranged funding from the legislature ($8.7 million over three years) for studies to be conducted by researchers selected by an administrator at UCSD… The researchers used marijuana grown at the University of Mississippi for the National Institute on Drug Abuse, Grant said matter-of-factly. I was reminded...

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Happy Birthday, Carl Linnaeus

 May 23, 2017   Carl Linnaeus was born on this date in Uppsala, north of Stockholm, in 1707.  Last July, James Prosek, a painter and writer, retraced part of the journey that Linnaeus made at age 25 to Swedish Lapland. At the outset, Prosek found something “distasteful” about the binomial nomenclature that categorizes plants and animals by genus and species. As he recounted in the  New York Times: I think what bothered me was his hubris. Before binomials, names of plants in books were lists or strings of words that formed a kind of nuanced description. Plants and animals already had...

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