Category: CBDiary

Mechoulam on Clinical Evidence

From Raphael Mechoulam’s preface to an anthology published in 1973: … The aim of this book is to present the state of the art in cannabis chemistry, in pharmacology, and in the clinic. Although numerous symposia and reviews on cannabis have been published there has not been a book covering all these aspects. I believe that we have answered a need rather than just burdened the library budgets. The chemical chapters, for reasons stated above, present a more complete picture than the metabolic and pharmacological ones. In the latter the gaps in our knowledge are obvious and present a...

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PS from Sulak re Epilepsy & Behavior paper

By Fred Gardner    In “The Current Status of Artisanal Cannabis in the Treatment of Epilepsy in the United States,” co-author Dustin Sulak, DO summarizes a case involving a 10-year-old boy who was started on a THCA-rich extract.  We asked why THCA instead of CBD?  Sulak replied that THCA is often easier to come by. Plus: “When people respond to THCA they usually respond at a much lower dose than they do to CBD. As a result, the trial takes less time. When you start someone on low-dose CBD it can take several months to  work them up to the...

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‘Clinical Evidence’ Acknowledged in Epilepsy & Behavior

The journal Epilepsy & Behavior has just published a special issue entitled “Cannabinoids and Epilepsy” that includes a groundbreaking paper by Drs. Dustin Sulak, Russell Saneto, and Bonni Goldstein, “The current status of artisanal cannabis for the treatment of epilepsy in the United States.”   Goldstein  based her report on 225 patients with intractable seizures seen at her practice in the Los Angeles area. Saneto reported on 47 patients seen at Seattle Children’s Hospital. Sulak, who is based in Maine, contributed four detailed case studies. They aggregated their results: “Of 272 combined patients from Washington State and California, 37...

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When Reefer Madness led to March Sadness for UCLA

One of the 50 greatest basketball players of all time has written one of the 50 greatest autobiographies of our time! “Back From the Dead” by Bill Walton (Simon & Schuster 2016, 327 pages, $27) describes some of the highest highs a man can experience in an ebullient style that lifts you right into his joy. Some deep lows are described, too, involving physical pain. Walton has endured 37 orthopedic surgeries. If you’ve ever heard him doing color commentary on a basketball broadcast, you know the tone of reverence that Walton reserves for John Wooden, his coach at UCLA,...

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Is the FDA Worth Defending?

When the crude rightwingers take over, the sophisticated liberals start looking not-so-bad in the rearview mirror. We tend to forget how effectively they served the corporations. As the TrumPence Administration sets about destroying the Food & Drug Administration, I’m thinking twice about publishing in O’Shaughnessy’s a list of  35 FDA-approved pharmaceuticals that had to be withdrawn from the market when they proved harmful or ineffective.  I intended to run it because the FDA promotes the cult of the Randomized Controlled Trial —a cult that upholds marijuana prohibition. The Biomedical Establishment disparages all other formats in which evidence of safety and evidence...

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