Category: CBDiary

How CBD Regulates Gene Expression

By Adrian Devitt-Lee and Martin A Lee There is growing interest among medical scientists in the gene-regulating properties of cannabidiol (CBD), the non-psychoactive plant cannabinoid. Researchers at the California Pacific Medical Center have shown that CBD reduces brain cancer and breast cancer cell proliferation and metastasis by inhibiting the expression of the ID-1 gene. ID-1 expression is implicated in several kinds of aggressive cancer. In 2012, Israeli scientists identified more than 1,200 genes affected by CBD. Some 680 “gene transcripts” were upregulated (“turned on”) by CBD and 524 were downregulated (“turned off”). The probe focused on CBD’s role in...

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Antioxidants and CBD

A warning From Joe D. Goldstrich, M.D., a reassuring response from Dustin Sulak D.O., and an additional comment from Goldstrich, December 4-8. First the warning:   The attached review article is seminal and its main message needs to be widely disseminated, in my opinion. Many people who use CBD as part of their treatment for cancer are also taking a lot of supplements, many of which have antioxidant properties. Antioxidants appear to reverse the cancer-inhibiting properties of CBD. Vitamins C and E, curcumin, CoQ10, etc., they all need to be stopped when CBD is used for cancer, in my opinion. The...

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Dr. Gedde Reports Her Findings

Margaret Gedde, MD, is the Colorado Springs physician to whom Paige Figi brought five-year-old Charlotte for approval to medicate with cannabis in February 2012. Charlotte was Gedde’s first pediatric epilepsy patient. As of September 2014 she had seen 187, and the influx was not slowing down. Back in 2012 Paige Figi had arranged with the Stanley Brothers, owners of two local dispensaries, to keep her little girl supplied with oil extracted from a CBD-rich strain they dubbed “Charlotte’s Web.” She spread the word about Charlotte’s progress online. Another Colorado Springs mom who consulted Dr. Gedde, Heather Jackson, began treating...

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The Rediscovery of CBD

By Fred Gardner    Before the first lab began testing cannabis for Harborside Health Center in the winter of 2008/09, it was widely assumed that cannabidiol —CBD— had been bred down to trace levels in the Cannabis being grown in California for medical and recreational purposes.  Overseas, scientists had been studying CBD. Their findings, as reported in journal articles and at conferences, suggested that CBD could be effective in easing symptoms of a wide range of difficult-to-control conditions, including rheumatoid arthritis, diabetes, alcoholism, PTSD, epilepsy, antibiotic-resistant infections and neurological disorders. CBD has also demonstrated neuroprotective and anti-cancer effects. The reduced...

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Introducing the International Cannabinoid Research Society —and CBD

By Fred Gardner In the summer of 1999 I was finishing my 13th year as managing editor of Synapse, the UC San Francisco weekly. The paper was staffed and produced mainly by medical students, with grad students and students from the schools of Pharmacy, Nursing and Dentistry also taking part. In July and August, with the students gone, Synapse appeared monthly and I did some of the writing. In June of ’99 I had attended the International Cannabinoid Research Society meeting in Acapulco, and the meeting provided a perfect hook for a Synapse story! UCSF pharmacologist Lester Bornheim presented...

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