Dispatches

Sophie’s Progress

From Tracy Ryan, June 24, 2014   Sophie has been on high concentrated THC and CBD cannabis oil at a gram a day since she started chemo in October of 2013. We worked her up to that dose slowly and the only side effects she ever had was a little sleepiness that completely went away as she acclimated to the oils.  Now her only side effect is hunger which is amazing since the chemo can affect her appetite.

When we give Sophie her medicine we separate them into 4 doses and give them 3 hours apart.  The experts that we work with believe that by separating the THC and CBD it allows the THC to attach to the CB1 receptors, and the CBD to attach to the CB2 receptors without competition which results in better absorption.  We truly believe that THC plays a huge part in killing her tumor, and she has continued to be on approximately a 2:1 ratio of THC to CBD.  The results we are seeing are just incredible!

Sophie’s tumor has surpassed everything that doctors told us was possible with chemo alone, and we are only at month 9 of a 13 month chemo protocol.  Because of the amount of shrinkage we are seeing we truly believe we’ll be able to quit chemo after her next set of scans in 2 months. read more

CBD for Epilepsy: Results From Dr. Goldstein’s Practice

CBD-3d

By Fred Gardner, June 17, 2014

Coincidentally, a British pharmaceutical company and a Los Angeles physician both reported data this week documenting significant seizure reduction afforded by CBD (cannabidiol, a non-psychoactive component of the Cannabis plant) in the treatment of pediatric epilepsy. Unsurprisingly, the levels of effectiveness reported by GW Pharmaceuticals and Bonni Goldstein, MD, were quite similar.

Goldstein may be unique among medical cannabis specialists in that she is a pediatrician. This has made her the go-to doctor for many parents whose children have severe forms of epilepsy. “A seizing child doesn’t scare me,” she says matter-of-factly.

Goldstein graduated from the Robert Wood Johnson Medical School in New Jersey and did her internship, residency and Chief Residency at Childrens Hospital Los Angeles. She worked in Critical Care Transport and Pediatric Emergency Medicine for 12 years before focusing on Cannabis Therapeutics. She sees patients in an office in Lawndale (Los Angeles County) and is the director of Canna-Centers, which has five offices in California.

On June 10 Goldstein, speaking at a benefit for the Epilepsy Foundation of Greater Los Angeles, provided some statistics from her practice. read more

First data promising: Epidiolex reduces seizure frequency

By O’Shaughnessy’s News Service, June 17 2014

Since the start of 2014, the British company GW Pharmaceuticals has been providing Epidiolex, a Cannabis extract that is 98% CBD, to pediatric epilepsy patients being treated by neurologists at medical centers in the U.S.  On June 17 the company announced efficacy and safety data on the first 27 patients to have been treated for 12 weeks by Orrin Devinsky at NYU School of Medicine and Roberta Cilio at UC San Francisco. Each patient’s frequency of seizures had been determined prior to treatment with Epidiolex to establish their baseline.

From GW’s  informative announcement:

• 48% of all patients obtained at least a 50% reduction in seizure frequency compared to baseline seizure frequency.

• 41% of all patients obtained at least a 70% reduction in seizure frequency.

• 22% of all patients obtained at least a 90% reduction in seizures.

• At the end of 12 weeks, 15% of all patients were seizure-free.

read more

Correa in Context

THM '99 in Acapulco

We live in a twittery world. A state senator, a rightwing Democrat from Orange County named Lou Correa, introduces a bill at the behest of law enforcement lobbyists to “regulate” the medical cannabis industry. Some dispensary operators whose niches would be secured by the bill meet with the state senator and discuss modifications. At the urging of Don Duncan of ASA, The Society of Cannabis Clinicians drafts a letter to the senator, diplomatically expressing their members’ objections to the bill. The letter ends with a long list of suggested changes to the wording.

Because it’s a twittery world, the merits of the Correa bill are debated without reference to the relevant background. And because the SCC doctors have their credibility as professionals to uphold, their letter cannot simply say, “It is against the state constitution for you and your cronies to weaken an initiative passed by the voters. It’s too bad that we, the people, can’t sue legislators who intentionally waste our money with bills that please their lobbyist/backers but won’t pass muster legally. Your bill is the political equivalent of malpractice.” read more

Remembering Ringo

April 5, 2014 By Fred Gardner    Lawrence Ringo died yesterday. Cancer. Cigarettes. Not yet 60. 

He was a tough guy in love with life, fulfilled by what his own life contained: plants and music, friends and family.

I met him in the winter of 2008/09 through Samantha Miller of Pure Analytics lab, who’d heard we were on the lookout for CBD-rich plants. I interviewed him that day  for the Anderson Valley Advertiser. Unlike most growers and plant breeders, who are understandably reticent when it comes to describing their work, Ringo was bold and forthright. He (and Samantha) gave Project CBD a great boost in those bygone days when we still felt it necessary to define cannabidiol for readers of the AVA. 

Sour Tsunami Stabilized! 

For the first time, a California plant breeder has “stabilized” a strain of Cannabis high in cannabidiol —CBD, the non-psychoactive cousin of THC that has medical benefits of its own. 

Lawrence Ringo, 54, runs the Southern Humboldt Seed Collective. He started growing marijuana at 15.  On his way to school one day he found a sapphire gold ring and a snub-nosed .38 and a film can of cocaine. He threw away the coke and returned the ring and the pistol to the local head of the Hell’s Angels.  “Come on in little brother,” said the grateful biker. When he asked what he could do by way of thanks, Lawrence pointed to a big Sativa plant he saw growing in the back yard and said, “I want to learn how to grow that!” read more

Realm of Caring Comes to California

By Fred Gardner   There is a point at which a story achieves critical mass —it goes from being a matter of interest to a fraction of the public to one that everyone’s talking about, inescapable in the media. That point in the medical cannabis story was reached last August when Sanjay Gupta, MD, narrated an hour-long “Special Report” on CNN that provided dramatic examples of Cannabis exerting beneficial effects. Most memorable was the return to health of a five-year old in Colorado Springs, Charlotte Figi, afflicted with Dravet Syndrome, a severe form of epilepsy.

Charlotte’s parents told Gupta how her condition worsened as every conventional treatment failed. She was having hundreds of seizures a day and the doctors were considering inducing a coma to save her life. Her dad, a Special Forces soldier deployed to Afghanistan, researched epilepsy treatments on the web and learned about CBD. Desperate, the Figis bought $800 worth of CBD-rich Cannabis at a dispensary and a friend helped them extract the medicine for under-the-tongue application. Charlotte’s seizures went down to one a week and and she began recovering!  read more

Dr. Goldstein on Caring for Kids With Epilepsy

By O’Shaughnessy’s News Service February 24 2014   Bonni Goldstein, MD, flew into San Jose yesterday to address some 120 serious, devoted, desperate, courageous parents on the subject of “CBD and Pediatric Epilepsy.” Goldstein is 40-something and could be Bette Midler’s body double (or vice versa).  The seminar was held at the Embassy Suites hotel in Milpitas, and was organized by Realm of Caring California, a foundation associated with the Stanley Brothers of Colorado. An extract from the Stanleys’ CBD-rich plant provided dramatic seizure relief to a little girl named Charlotte Figi, whose improvement was reported to the world by Dr. Sanjay Gupta on CNN last summer. The strain was dubbed “Charlotte’s Web.” Many of the parents who came to hear Goldstein are on a waiting list to get oil made from Realm of Caring plants being grown by Ray Mirzabegian, who also spoke.

 Goldstein is the medical director of Canna-Centers, a chain of clinics. She had previously given seminars in concert with Realm of Caring in Santa Monica and Irvine. “There’s a lot on the internet that’s opinion,” she said, “I’m here to give you the facts.”   read more

San Francisco Narcs Get a Small Come-Uppance

sf_hall_justice

February 28, 2014   San Francisco Police Chief Greg Suhr says he’s “shaken” by the federal indictment of five SFPD narcotics officers. Bwa bwa bwa, as Dennis Peron used to say.  The criminal behavior perpetrated by Suhr’s troops was standard operating procedure and he knows it. He’s shaken that the men got caught on camera doing their thing —ripping off poor people and planting drugs— and that the feds did not give them a pass. Chris Roberts wrote about Chief Suhr’s response to the indictment in yesterday’s San Francisco Examiner. Nobody on the Police Department’s command staff is suspected of wrongdoing,” according to Suhr (according to Roberts), and “there is no evidence of a systemic problem throughout the SFPD.”

Greg Suhr is himself a former SFPD narcotics officer and a longtime honcho in the narco-clique that, for about a decade starting in 1996, did not completely rule at the Hall of Justice. (Terence Hallinan was DA, Willie Brown mayor, and Fred Lau and Heather Fong running SFPD in this interlude. Gavin Newsom restored Suhr to power as he left for Sacramento to become Lieutenant Governor.) read more

Dr. John Merritt’s Call to Reschedule Marijuana

It’s Black History Month (we knew her when she was Negro History Week) and O’Shaughnessy’s is honoring some African Americans whose contributions to the abolitionist cause have been under-publicized. 
 
In July 1976, Washington, D.C. Superior Court Judge James A. Washington —a former dean of Howard University Law School— ruled that Robert Randall, a D.C. resident in his 20s who was going blind from glaucoma, had a right by way of “medical necessity” to use marijuana. Key testimony came from a UCLA opthalmologist who had observed Randall’s response to the available pharmaceuticals and found that only marijuana lowered his intraocular pressure.  Following Judge Washington’s ruling, the Food and Drug Administration agreed to provide Randall with marijuana grown at the University of Mississippi for the “research purposes” of the National Institute on Drug Abuse.
 
First, however, Randall had to find a Washington-area opthalmologist willing to prescribe the “investigational new drug” and supervise his treatment with it. (The opthalmologist who had previously treated him wanted nothing to do with marijuana.) Coincidentally, in August ’76, John C. Merritt, MD, an assistant professor of Opthalmology at Howard University College of Medicine, notified the National Eye Institute that he wanted to study the effect of marijuana on glaucoma. NEI told NIDA, and doctor and patient were hooked up.

read more

Support O’Shaughnessy’s

"From each according to their ability, to each according to their need." 

O’S Available Here

O’S First E-Book – Available Now!

Recommended Reading

Plugs

Prop 215 Ballads – Fred Gardner’s CD Medical Cannabis Videos

Our Entourage

Best newspaper in America Dr. Tod – The Movie The Society of Cannabis Clinicians was formed as a project of the California Cannabis Research Medical Group in the Autumn of 2004. Project CBD is a non-profit educational service dedicated to promoting and publicizing research into the medical utility of cannabidiol (CBD) and other components of the Cannabis plant. News and political analysis Dr. Lester Grinspoon, M.D. is Associate Professor Emeritus of Psychiatry at Harvard Medical School. Dr. Grinspoon was senior psychiatrist at the Massachusetts Mental Health Center in Boston for 40 years. Moving Sustainable Medicines Forward Consultant VaporNation Newhead News Political allies CRAFT Law Office Omar CBD specialists
"Experience is useless without memory."
—Martha Gellhorn

The Second Column

Public Health Service Approves Sisley’s PTSD Study

Sue Sisley

March 14, 2014      This is said to be a big, big breakthrough. Here’s the relevant background. And here’s the latest from Evan Halper (from Washington) and Cindy …

They’re Allowed to Shoot Children on the Street

Andy Lopez —photo by Bridgett Roque

From O’S News Service July 8, 2014 Last October a Sonoma County Sheriff’s Deputy —an Iraq vet named Erick Gelhaus— fired seven rounds into a 13-year-old named Andy Lopez who was …

On “Runner’s Joy”

Men's Health Cover

From Greg Gerdeman, July 8: My little Men’s Health info graphic on runner’s high is out. I didn’t do the design. Get your souvenir copies on magazine stands …

Sophie’s Progress

Dad, Sophie, Mom

From Tracy Ryan, June 24, 2014   Sophie has been on high concentrated THC and CBD cannabis oil at a gram a day since she started chemo in October of …

Cannabis vs Glioma: Another Encouraging ‘Anecdote’

Sophie Ryan

From Bonni Goldstein, MD, June 20, 2014 I have a patient who is almost two years old who has a terrible brain tumor called an “Optic Pathway Glioma.” …

Plant Geneticist Seeking Unhybridized Strains

Jon Page (right) with Alexander Makryannis at the 2011 ICRS meeting.

From Robert Sutherland of the Humboldt-Mendocino Marijuana Advisory Project June 23, 2014 At the Hummap meeting in Redway yesterday, the main agenda item revolved around genetics, and the …

Introducing ‘Cannabis as a Substitute for Alcohol’

THM 21_1

By Fred Gardner   June 18 WeedMaps is planning to post O’Shaughnessy’s Greatest Hits, starting with Tod Mikuriya’s paper “Cannabis as a Substitute for Alcohol” (2003). The name of Tod Mikuriya, …

Cole/Anslinger

Deputy AG James M. Cole

Leaders of the marijuana industry greatly appreciated the line Deputy Attorney General James M. Cole took in 2013 when he told Congress: “The Department of Justice expects that states …

Cannabis for Camraderie

60minutes ptsd

Ellen Komp points out an overlooked beneficial effect of cannabis in a note sent May 26: Remarkable story on 60 Minutes last night about veterans with PTSD, diagnosed now in …

JAMA scopes out Colorado

Dr. Larry Wolk

May 14, 2014  By Bridget M. Kuehn for JAMA Online: When Colorado legalized possession of small amounts of marijuana in January, the action catapulted the state to the …

“America’s Most Progressive D.A.”

Brooklyn DA Kenneth Thompson. Photo by Michael Nagle for the NY Times

By O’S News Service April 24, 2014   The title once claimed by Terence Hallinan of San Francisco now goes to Kenneth P. Thompson, the district attorney of …

Honest Talk About Heroin

graphic by Jungyeon Roh

April 17   A great musician named Robert Aaron was arrested by publicity-seeking New York City cops shortly after Philip Seymour Hoffman died in early February. Aaron was …

WeedMaps Billboard Banned From Times Square

CBS_Super_Screen_NADA_1000

By David Downs in the East Bay Express, April 15   Even though polls show that most Americans support the legalization of marijuana, corporate America continues to censor pot-related …

Frankel to San Diego: Extracts are Essential

Dr. Frankel

From Allan Frankel, MD, April 13:   I was asked to either attend a City Council meeting in San Diego or write a letter. The city is looking to …

The Taming Role of NGOs

Arundhati Roy

April 9  The renowned Indian novelist and essayist Arundhati Roy explained on Democracy Now today how non-governmental agencies —foundations and other non-profits— move in on indigenous reform efforts, …

Shack Attack (add CBD strains)

ShackAttack-week9_2

From David Bonvillain in Colorado, April 10: In honor of the mentor I never got to meet in person —thought I would share my latest results from some …

Gerdeman to Florida Pols: The Science is Indisputable

Greg Gerdeman

By Gregory Gerdeman in the Tampa Bay Times April 8 The science is indisputable: marijuana is medicine There appears to be growing support in the Legislature to legalize …

Michelle Leonhart and the scandal that wasn’t

leonhart_thumb

April 5   DEA Michelle Leonhart, addressing a law-enforcement conclave in March, expressed misgivings about the Obama Administration’s supposedly lenient approach towards marijuana. Pro-cannabis activists  were shocked —shocked— …

A Tribute to Ringo

Ringo in the sun.

From Kerry Reynolds of KMUD  April 5, 2014     Here’s a link to my Cannabis Consciousness episode in February, when we just found out about Ringo. Ringo …

CBD for Dental Pain

Dr. Frankel

Case note from Allan Frankel, MD, April 3, 2014 In the past few days I have been following a 59-year-old woman with severe pain following gum surgery. An …